Yes it's significant, that's why I don't like vendor lock-in. It's very simple to use VMs on various cloud providers but as soon as you use their more integrated products, it can be a disaster.
Vendor lock-in can be a real issue as you scale. I work at a company going through a hypergrowth phase, and we're more or less locked into Azure, which has been objectively awful for us
I see your architecture highly exposed to vendor lock-in. Also, your operations cost could become non-competive since you lack leverage to negotiate (b/c vendor lock-in). Finally, it seems hard to monitor and maintain.
Vendor lock-in is what they're after in the cloud case. Every time we talk to our cloud provider reps they ask us which of their SaaS offerings we're using. Their heads spin when we tell them we're just using VMs and ask us why.
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