I've recently started writing all my scripts in Python 3 as I need to future-proof some things. And it just works now. No problems. So if you tried Py3 years ago and had issues, try again today.
Py3 has been prime time for a while now. Been using it full time since Py 3.3 for all my work and I haven't had any issues with it. There were some external libraries such as the library given by a twilio competitor that were incompatible, but easily fixed (almost exclusively, encoding issues).
Although, I still find myself running tests and cursing at the fact that I keep writing print "string" without the brackets :D
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