It's pretty much a wash. The reason wheels are bigger is for better handling as well as space for larger disc brakes. The combined total weight of brake disc, tire, hub and rim is roughly a constant due to the use of lighter materials.
Bigger wheels reduce the need for suspension to keep the wheel in contact with the road, so there may be a tradeoff that makes sense being made in this case.
I'm guessing, the larger single wheel gives you a smoother ride? They're easier to pick up and carry like a briefcase, too. But I imagine, harder to ride.
Within reason, larger wheels and slimmer tires do more for the car aesthetically. Look at any concept sketch from an automotive designer and you will find impracticably big wheels on the design.
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