There was never a major mRNA vaccine roll out ever. mRNA possibly does not compare to traditional vaccines, there's evidence it is a different beast entirely.
Enough reason to be cautious, wait out the hidden/late-onset side effect, and not give it to those not too vulnerable to covid.
But authorities claim it's totally safe for all ages, while they have no data to back this up (that'd need a long trial, and those taking it ARE the long trial).
I understand that, I just have concerns regarding the safety of this particular vaccine. They say it is revolutionary, but if this is really that, then is this not a new vaccine with unknown long-term risks? I read this on CDC's website: "There are currently no licensed mRNA vaccines in the United States. However, researchers have been studying them for decades.". This is not too convincing still.
No mRNA vaccine has been approved before, but from clinical trials of mRNA vaccines dating back to 2008 [1] there’s evidence of short-term side effects but no reason to suspect long-term safety concerns. mRNA vaccines don’t present the risk that attenuated vaccines pose to immunocompromised individuals or pregnant women, and they don’t stay in the body long enough to be a long-term threat. We can’t guarantee 100% because our bodies are complex, but I wouldn’t characterize it as “significant increased risk” for people under (or over) 40.
Wouldn't this be the first mRNA vaccine approved for the public?
I know very little about the pharmaceutical underpinnings of mRNA vaccines and how theoretically likely adverse long-term results are, but I do think caution by laymen is not unwarranted for a new type of vaccine that has been fast-tracked through trials (albeit for good reason!)
I'm not getting into the relative merits of vaccination, I'm merely saying that mRNA isn't going to hurt you. Even decades from now. We know there are no medium-term risks of mRNA therapies because the otherwise healthy people who have injected themselves with mRNA are still alive and kicking.
Here is the first Phase I test of an mRNA vaccine from 2013.
Exactly. The vaccines did not go through the FDA’s typical approval process, they got emergency approval, but the standard approval process is still ongoing. mRNA vaccines have never been used in a large scale setting outside of clinical trials before. Are they safe? Almost certainly. Do we know that for sure yet? No. Do the benefits outweigh the risks? For me, yes.
mRNA vaccines have been researched for decades, and the only really novel part of the covid vaccine is the particular protein, which will also be present in a natural infection.
So if you trust the decades of mRNA vaccine research, you should consider the vaccine strictly safer than covid, as getting the disease will expose you to everything the vaccine exposes you to.
mRNA vaccines are not new, just newer than existing platforms. mRNA vaccine clinical trials which usually last years (or a decade), were completed in 2017, as per the nature article summary. The technology and its effects are well known in both in mice and human models.
Is there residual risk that there were will be some unintended side-effect when billions of doses are administered? Yes, of course. There is no way to prove a vaccine is safe for everyone in all conditions, (see: Popper's falsification and the demarcation problem). Same goes for any other pharma formulation, food stuff or procedure. However, we have to weigh the residual risks against the risk of death from Covid and its variants and risk of long term damage to me or those around me who might be unwittingly in a higher risk category.
Vaccination is a moral obligation and even if I would rather not, decency and civic duty to our fellow humans dictates that I must. And so should you.
Does this vaccine actually provide immunity like normal vaccines? The mRNA one apparently didn't stop you catching or spreading covid which really makes me wonder why it is being pushed so hard when the virus isn't actually a danger to most healthy people under 65.
There's no evidence of any risk of mRNA vaccines at all. The only issue so far has been extremely rare blood clot issues with the adenovirus vaccines (AstraZeneca & J&J).
The vaccines are not approved for children under 12 because the risks to young children from the virus are the lowest of any population group, so older groups were prioritized for efficacy and safety testing. It is being tested now in that age group (I know people with kids in the trial group) and will hopefully be approved shortly.
If this virus worked the way the flu does, doing the most damage to children and the elderly, then the vaccine would have been tested on children much sooner and would have been available to that group sooner. In that world, that's not because the vaccine was more dangerous to 25 year olds.
Yes but these are known variables. Hypothetically the newer mrna vaccines should be safe .... but there honestly is no long term information. A MRna vaccine has never been approved for human use until now.
You don't have to trust the FDA or CDC. The mRNA platform is quite old relatively, and millions of doses have been administered with profoundly low adverse effects.
Could you please name any other mRNA vaccine that was authorized for use in humans by FDA? I am not aware of any.
I agree that the vaccine is probably safer. However, propaganda that covid19 infection doesn't give you as good immune memory as the vaccine is outright false and should be considered as vaccine misinformation on major platforms.
There is no reason to believe mRNA vaccine technology poses any particular risk compared to conventional vaccines. In fact, I would be willing to bet that they're less likely to cause problems than viral vector vaccines.
Previous attempts at mRNA vaccines had failed, due to the side effects being too serious. There was no reason to believe in May 2020 that a COVID mRNA vaccine would be any different than all the previous mRNA failures.
Are mRNA vaccines safer than traditional ones? In the long run, which one will have less side effects? As far as I know, Both US and Europe are only going with mRNA vaccines for COVID. Is it intentional or just because there is no traditional vaccine that completed Phase III trials?
mRNA will eventually save the day for everyone, including for perfectly healthy individuals, but to me as a healthy 40yo person, with no known immunity issues, not overweight etc. etc. it is in my opinion still too risky to take just like that.
It's an interesting take. From what we know so far, the risk from taking vaccine is much smaller than from covid infection. You might counter this with highlighting the "so far" part, but keep in mind that many studies keep coming out with surprises not only regarding vaccine side effects, but also negative long term effects of covid.
Enough reason to be cautious, wait out the hidden/late-onset side effect, and not give it to those not too vulnerable to covid.
But authorities claim it's totally safe for all ages, while they have no data to back this up (that'd need a long trial, and those taking it ARE the long trial).
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