What is most telling about all of this is that there is no honest discussion. My only initial comment was that this blocks the same protein that ivermectin does. Multiple studies confirm this, its easy to search for them, and it has been the hypothesized mechanism by which ivermectin may show some efficacy.
He's saying that none of these studies have shown in the real world that ivermectin effects TMPRSS2. And I've been trying to have an honest discussion from the beginning. I said I'd failed to find what you were claiming, but tried to make it clear that I was listening if you did have some evidence. Luckily you did, but analyte123 pointed out it was weak.
This paper seems to to be a survey of other papers so doesn't actually provide any new evidence itself. It also has a few grammar issues which makes me more skeptical of it, but whatever. The claim made as I understand it is that there is only very weak evidence that `ivermectin` might effect `TMPRSS2` (aka computer models). Since we've done randomized controlled trials we can be fairly confident that ivermectin doesn't work to treat covid. The best evidence I've heard of for it working came from cell cultures where at very high concentrations it was able to prevent covid from entering cells so maybe the mechanism there even is related to TMPRSS2, but I'm just not really sure of what discussion you were expecting.
Your comment read to me like you see this as vindication that ivermectin is likely to be an effective drug, when it sounds like TMPRSS2 has been consistently targeted as a treatment for covid by a number of different drugs and you've still only shown at best weak evidence that ivermectin even effects it
As far as I can tell ivermectin has only been "studied" against TMPRSS2 in silico. The better-studied purported mechanism of ivermectin against SARS-CoV-2 involves something called importin [1]. On the other hand, bromhexine, which is a cough medicine used OTC around the world does inhibit TMPRSS2 and may have action against SARS-Cov-2 [2]. Bromhexine is a prodrug for ambroxol, which is also an OTC cold medicine in much of the world.
Some quick googling doesn’t back this up and my understanding is that ivermectin has only shown itself to be effective at doses that are higher then are remotely safe. It also just isn’t the sort of thing there would be incentive to lie about. Probably then the straightforward story is true no it’s only effective as prescribed as treatment for parasites. If you’d like to provide some sources though or more explanation that would be great.
Note that TMPRSS2 has been a potential target for treating covid basically since the beginning, so some one lying and claiming it as a mechanism of action isn’t surprising
There does seem to be some protease inhibition involved.
An in silico data analysis conducted by Choudhury et al. demonstrated that ivermectin efficiently utilizes viral spike protein, main protease, replicase, and human TMPRSS2 receptors as the most possible targets for executing its "antiviral efficiency" by disrupting binding.[1]
No, no. You have to give a source! Like CNN, or MotherJones! Until then there's no way to know the truth about whether ivermectin blocks this protein or not. I mean there isn't even really a right answer to that question, until we hear it from reliable sources!
This article explains the suspected mechanism of action. I'm not claiming that ivermectin is actually effective, but the biochemistry is at least plausible.
> Ivermectin binds to glutamate-gated chloride channels and is used to treat parasite infections, said Joseph Glajch, a consultant in pharmaceutical and analytical chemistry.
> “These two are so far apart,” he said. “If you look at how they interact with the body..., they don’t even go to the same pathways or receptors.”
Ivermectin acts on glutamate chloride ion channels. It is not a protease inhibitor. And even if it were (which it is not), something that inhibits one protease doesn't work on other proteases. We can't use HIV protease inhibitors to fight covid, for example.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372205/
What is most telling about all of this is that there is no honest discussion. My only initial comment was that this blocks the same protein that ivermectin does. Multiple studies confirm this, its easy to search for them, and it has been the hypothesized mechanism by which ivermectin may show some efficacy.
Does ivermectin block TMPRSS2 or not?
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