I've posted this before regarding the SA paper on AZ, worth taking a look at the below.
The probable outcome is minor to moderate symptoms that would normally be blocked by antibodies can still present (So no reduced transmission) but severe symptoms are still prevented by the vaccinated patients T-cells response.
This paper is looking at a small scale human study in SA with mostly younger participants, which does make the results difficult to apply to the wider population.
They also only use a 4 week dosing schedule where the suggestion and actual rollout in the UK is following the 10-12 week schedule between first and second doses which was shown to increase efficacy from ~70 to ~80% after the second dose (UK - Kent variant)
The variant in question seems to escape the majority of Antibody detection, but T-Cells still seem to provide significant protection against severe disease and death.
The main published results aren't yet from human scale studies but here is one in hamsters showing a comparison in organ damage and results between unvaccinated and vaccinated with the Oxford/AZ vaccine.
The probable outcome is minor to moderate symptoms that would normally be blocked by antibodies can still present (So no reduced transmission) but severe symptoms are still prevented by the vaccinated patients T-cells response.
This paper is looking at a small scale human study in SA with mostly younger participants, which does make the results difficult to apply to the wider population. They also only use a 4 week dosing schedule where the suggestion and actual rollout in the UK is following the 10-12 week schedule between first and second doses which was shown to increase efficacy from ~70 to ~80% after the second dose (UK - Kent variant)
The variant in question seems to escape the majority of Antibody detection, but T-Cells still seem to provide significant protection against severe disease and death.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid...
https://www.biorxiv.org/content/10.1101/2021.03.11.435000v1
The main published results aren't yet from human scale studies but here is one in hamsters showing a comparison in organ damage and results between unvaccinated and vaccinated with the Oxford/AZ vaccine.
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